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De lactibus sive lacteis venis quarto vasorum mesaraicorum genere novo invento... dissertatio., ASELLI, Gaspare (1581-1625).
1 ASELLI, Gaspare (1581-1625). De lactibus sive lacteis venis quarto vasorum mesaraicorum genere novo invento... dissertatio.
Milan: Giovanni Battista Bidelli, 1627. 1627 
4to. [24], 79, [1] pp. [Collation]: †4, †4, †4, A-K4. Engraved title and engraved portrait of the author by Cesare Bassano, both conjugate with text leaves. 4 large folding chiaroscuro woodcut plates printed in black, dark red, and light red; occasional light spotting or foxing. Pages 75-78 showing a neatly closed tear. Original full vellum; upper corner showing a bit, some minor cover stains, but very well preserved in the original binding. Bottom fore-edge: early manuscript inscription representing the title [“Aselli De lactibus ...”]. Very good copy. FIRST EDITION: “Records the discovery of the lacteal vessels. Aselli’s book has also the distinction of including the FIRST ANATOMICAL PLATES PRINTED IN COLOURS (FOUR CHIAROSCURO WOODCUTS, 16" x 10").” – Garrison and Morton. “Aselli ..., who had been a pupil of Fallopius, practiced as a surgeon in Milan. There he continued his anatomic research and wrote in a more dynamic manner and with greater physiologic insight than has his predecessors, whose approach had been essentially teleologic and descriptive. Although Aselli’s notebooks and jottings for lectures have never been published, he is renowned for this small volume, which was published two years after his death at the age of forty-five. ‘The book records his chance discovery of the lacteal vessels in 1622 while he was displaying the mesenteric nerves of a dog at an anatomic demonstration. In this fed animal, he noted a network of mesenteric vessels that contained a whitish fluid. Because such engorgement was absent in a fasting animal, he concluded that it was related to recent feeding. “Writing before the publication of Harvey’s work on the circulation, Aselli maintained that the liver was the center of the venous system and believed, as did Galen, that the intestinal veins carried chyle to the liver. Harvey knew that the Galenic account was wrong and remained skeptical about the existence of lacteals; the contradiction was cleared away when Jean Pecquet announced his discovery of the thoracic duct in 1651. “In his text, which comprises thirty-five chapters, Aselli took up the intestines in general, their veins, arteries, nerves, and a ‘fourth, new kind? of vessels. He explained why he had named the vessels and asked why they remained undiscovered for so long. He presented their anatomy in great detail and wondered whether they were supplied with chyle or blood. He also described the transit of chyle to the liver and discussed the contribution of the new vessels to the formation of blood. “The book was illustrated with a copperplate portrait of the author at the age of forty-two, when he made his discovery, and with four large foldout plates showing the lacteals in animal dissections. These are most remarkable woodcuts, both for their display of the dissections and for the method in which they were produced... The Aselli plates were the first colored illustrations in an anatomic text.” – Lilly-LeFanu, Notable Medical Books, p. 61. PROVENANCE: Rubber-stamp of Doctor Mario E. Spada, a 20th century surgeon. REFERENCES: Choulant-Frank, pp. 240-41; Garrison and Morton 1094; Grolier, One Hundred Books Famous in Medicine, 26; Heirs of Hippocrates 453; Krivatsy 446; Lilly, Notable Medical Books, 61; Haskell Norman 76; Osler 1846; Waller 502; Wellcome 6837. First Edition. 
Price: 89500.00 USD
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2 BERNARD, Claude (1813-1878). An introduction to the study of experimental medicine. Translated by Henry Copley Greene, with an introduction by Lawrence J. Henderson.
New York: Macmillan, 1927. 1927 
8vo. xix, 226 pp. Original full green blind and gilt-stamped cloth. Waterstained, occasional ink underlining and marginalia. Ownership signature of I.L. Chaikoff. Good. First English translation. “Probably the greatest classic on the principles of physiological investigation and of the scientific method as applied to the life sciences.” PROVENANCE: Israel Lyon Chaikoff (1902-1966), was a professor of physiology at UC Berkeley. For first edition see: Garrison and Morton 1766.501; Grolier Club, 100 Books, 67; Heirs of Hippocrates 1797; Horblit 116; Norman Library 206; Osler 1511; Printing and the Mind of Man 354; Waller 951. First Edition. 
Price: 30.00 USD
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Memoires, sur la Nature Sensible et Irritable, des Parties du Corps Animal…., HALLER, Albrecht von (1708-1777).
3 HALLER, Albrecht von (1708-1777). Memoires, sur la Nature Sensible et Irritable, des Parties du Corps Animal….
Lausanne: Marc-Michel Bousquet (part 1); Sigismond d?Arnay (parts 2, 3, 4), 1756-1760. 1756 
Four volumes in two. 12mo. x, 399; [vi], 500; [ii], 512, [4], xxiv, 232 pp. Engraved frontis., titles printed in red and black, small title vignettes, tailpieces, 2 engraved folding plate (Vols. I facing p. 432; III facing p.322); couple of small marginal tears, tiny puncture affecting several leaves in Vol. II. Old tan boards re-backed with brown library cloth, original calf corners; corner calf a remnant, extremities showing, joints starting. Very good. Bookplates of Columbia University. Very good. Rare. FIRST EDITION IN FRENCH, translated by Samuel Auguste Tissot. Swiss scientist Albrecht von Haller, one of the greatest and most influential medical-biologists of the 18th century, has been called the “father of experimental physiology.” He notably “distinguished between nerve impulse (sensibility) and muscular contraction (irritability).” – Garrison and Morton 587. Contents: [vol. I] Expose analytique des resultats des experiences …; Sur les parties irritables luë 6. de mai 1752; Sur les parties irritables … Expose synthetique des faits …; Sur l?insensibilite …; Sur l?insens. De la dure mere; Exp. Qui servent à la digression sur le mouvement du cerveau analogue à la respiration; Exp. Sur ‘insens.; Sur le sentiment de la substance medullaire du cerveau; Sur l?insensibilite des grandes membranes; Sur la sentiment des visceres; Liaison de la sensibilite à l?irritabilite; Du mouvement de l?iris; Sur l?irritabilite des vaisseaux du corps anime; Sur la vesicule du fiel; Sur la vessie & l?uretere; Sur l?uterus; Sur l?estomac & l?œsophage; Sur les intestins; Sur le mouvement du Cœur; Experiences qui ne reussirent point; Exp. qui ne prouvent rien [vol. II] Experiences de M. Zinn; Experiences de M. Zimmermann; Experiences de M. George Christian Oeder; Exp. de Mr. Castell; Exp. de M. Walstorf; Exp. de M. Heuermann; Memoire de M. Muhlmann sur les suites de blessures des tendons & du perioste; Premiere Lettre du R.P. Urbain; Memoire de M. Broklesby; Lettre de M. Cesareo Pozzi. Exp. de M. Graziani sur l?insensibilite des tendons; Troisieme lettre du P. Tossetti à M. Valdambrini; Preface du P.J. Vincent Petrini au recueil de Rome; Exp. de M. Berdot …; Lettres de M. Housset; Quatrieme lettre du P. Tosetti; [vol. III] Lettre de Mr. Antoine Caldani … [to] Haller; Dissertation Epistolaire de Mr. L?Abbe Felice Fontana; Remarques sur l?insensibilite de quelques parties etablie par la pratique, par Mr. Bordenave; Troisieme Section … de Mr. Jean François Cigna; Lettre de Mr. J.B. Verna … a Mr. Haller; Experiences de Mr. Achille Mieg; Quatre Observations sur l?insensibilite des tendons, par Tissot; Sur l?insensibilite et l?irritabilite de Mr. Haller, Seconde lettre de Mr. Marc. Antoine Caldani; Lettre de Mr. Jean Bianchi; Lettre de M. J. Baptiste Moretti, a m. de Haller. [vol. IV] Experiences nouvelles sur differents animaux vivans; Reponse generale aux objections qu?on a faites contre I ‘insensibilite de plusieurs parties du corps anime; Reponse à la Critique de M. Whytt; Reponse a la lettre de Mr. Lamure. “Francis Glisson (1672) introduced the idea of irritability in the second half of the 17th century, but it was mainly in the 18th century that it found such extraordinary success in the medical sciences, particularly thanks to Albrecht von Haller, who made it the central explanatory concept of his physiology (Haller, 1751, 1756-60). The idea of irritability indicates a property that permits the different parts of the living body to react independently from the conscious mind, the central nervous system, and the whole of the organism. Vital forces, notably the capacity to respond to stimulation, are, so to speak, ‘decentered,? even to the point that they become the characteristic property of the structural element of the body, the elementary fiber. Living, flexible, tensile, elastic, and above all irritable fibers are the seat and the cause of all reactions to exterior stimuli that produce expressions, emotions, and different vital phenomena. According to Haller, ‘fiber for the physiologist is like the line for the geometrician,? the measure allowing the whole of sensible objects to be built.” – Tom Cochrane, Bernardino Fantini, Klaus R. Scherer, The Emotional Power of Music: Multidisciplinary Perspectives on Musical Arousal, Expression, and Social Control. Oxford University Press, (2013), p. 259. “According to Tissot, Haller found irritability by getting rid of the ‘rubbish of a mass of imaginary systems.? On the basis of over five hundred experiments (generally vivisections), many cited in the Dissertation on the Sensible and Irritable Parts of Animals, translated by Tissot, Haller established that muscles contract when a stimulus is applied directly to them. He also showed that a stimulus applied to a nerve does not affect the nerve itself, but produces the contraction of the muscle connected to it. Irritability was therefore attributed to muscles, sensibility to nerves.” – Lorraine Daston, Fernando Vidal (eds.), The Moral Authority of Nature, University of Chicago Press, 2010, page 256. “Haller was a pioneering figure in the early days of neurophysiological research, being not only influential for establishing animal experimentation as a viable method to gain knowledge about (human) neurological functions. He also tackled the question of sensibility as the most fundamental property of living bodies, which came to influence our conception of bodily feeling.” –See Stephanie Eichberg, “Constituting the human via the animal in eighteenth century experimental neurophysiology: Albrecht von Haller’s sensibility trials,” in: Medizinhistorisches Journal, 44, (2009), pp. 274-295. REFERENCES: Garrison and Morton 587 [1752 first Latin ed.]; Michael J. O?dowd & Elliot E. Philipp, The History of Obstetrics and Gynecology, p. 256. Not in Heirs of Hippocrates; not in Waller. See also: Palmira Fontes Da Costa, “Albrecht von Haller and the Debate on the Existence of Human Hermaphrodites,” Portuguese Journal of Philosophy, 01/2010; vol. 41, 354, 811. WorldCat: UCLA; UCB; Bakken Library; University of Wisconsin; Northwestern University, Medical Library; University of Chicago Library; University of Michigan; Oberlin College Library; Duke University Libraries; University of Rochester Medical Center; Academy of Natural Science; Cornell University Library; Johns Hopkins Medical Institutions; University of Pennsylvania Libraries; McGill University Library; Universite de Montreal; Harvard University, Countway Library; Yale University; University of Edinburgh; University of Cambridge; University of Glasgow; Wellcome Library; The British Library. First Edition. 
Price: 2000.00 USD
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4 HUNTER, John (1728-93). A Treatise on the Blood, Inflammation, and Gun-shot Wounds. To which is prefixed, a short account of the authors life, by his brother-in-law, Everard Howe.
London: John Richardson for George Nicol, 1794. 
4to. lxvii, [1 blank], 575 pp. Frontispiece, 9 plates (one with 2 figures between pp. 160-61, the others at rear numbered I-VIII); plates foxed, occasional light scattered foxing throughout text. Modern quarter gilt-stamped calf over marbled paper-backed boards, gilt-stamped red leather spine label; corners faintly rubbed. Title-page inscription to W. Buxton from David Rice, 8/25/1820. Better than very good. SCARCE. FIRST EDITION [Grolier Club & Norman One Hundred Books Famous in Medicine, no. 52]. This remarkable, but typical, work of Hunter is based on his own observations during his military experience and is not in any way dependent on any other concepts. Its approach to physiology and pathology has a definitely modern ring. The book was finished but only about one-third through the press (in Hunters own home) when Hunter died. It contains nine fine copperplates in the text as well as an engraved portrait and a biography of Hunter (Heirs of Hippocrates 972). It was while serving with the army at Belle Isle during the Seven Years War that Hunter collected the material for his epoch-making book on inflammation and gunshot wounds. His studies on inflammation in particular are fundamental for pathology (Garrison & Morton 2283). Hunter, even more remarkable than his remarkable brother, Williamwas an anatomist and surgeon, practicing in London. He lacked the education and culture of his brother, yet his tireless energy helped him to overcome whatever obstacles his educational and cultural lacks may have provided (Heirs of Hippocrates 968). Hunter, with Par and Lister, [was] one of the three greatest surgeons of all time. (Garrison, p. 137). References: Garrison, Fielding H. An Introduction to the History of Medicine. 4th ed. Philadelphia: W. B. Saunders, 1929; Heirs of Hippocrates 968&972; Garrison & Morton 2283; Grolier Club & Haskell F. Norman, One Hundred Books Famous in Medicine (1995), no. 52; Osler 1230; Waller 4997; Wellcome III, p. 317. First Edition. 
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5 MALPIGHI, Marcello (1628-1694) & Pierre S. REGIS (1628-1694). Opera Posthuma. In quibus Excellentissimi Authoris vita continetur, ac pleraque ... Editio ultima figuris æneis illustrata, priori longe præferenda.
Amsterdam: Georgium Gallet, 1698. 1698 
4to. [2], [iii-xvi], 136, [137-38], 139-267, [268-271], 272-387, [1 blank] pp. Frontispiece, 19 numbered folding plates; extremities of pastedowns, frontispiece (gutter partly loose), title-page, and free end-leaves chipped, occasional light scattered foxing, not affecting legibility. Original full vellum, holograph spine title; soiled, spine foot torn. Library call number mounted at spine foot. Bookplate of Yale University Library, donated from the library of Professor John S. Ely, M.D., 1908. Title-page ownership signature of C. Helvigio, Lugd. Bat., 1710. Verso title-page ownership signature of Gustavus Guilielmus Henrici, D., 1769. Very good. FIRST AMSTERDAM EDITION, predating Garrison & Morton’s entry by 2 years (Garrison & Morton 4299), and succeeding the rare first edition published for the Royal Society by A. & J. Churchill in 1697. Opera Posthuma is divided into three sections. “The first section consists largely of correspondence arising out of Malpighi’s published works, on the viscera, heart polyps, silkworms, anatomy of plants and animals, helminthology, &c. The 19 plates at the end of the vol. belong to this section” (Osler 987). The second section, with its own engraved title-page, contains Malipghi’s “De structure glandularum conglobatarum,” followed by Alfonso Borelli’s “Scrittura fatta l?anno 1664 sopra le opposizioni delli Sig. Finchio, e Fava, Inglesi…” (Osler 740), followed by “Malpigi’s work (written in the name of his pupil, Placido di Papadopoli) in defence of his newer studies in anatomy against Liparo’s ‘Galenistarum triumphum?, 1665” (Osler 987). “A short report by J. B. Giraldus (with a sep. title-[age) is between Sbaraglia’s ‘De recentiorum medicorum studio? and Malpighi’s response thereto” (Osler 987). Borelli’s piece, Osler 740, first appears here in Malpighi’s Opera Posthuma. Osler’s 1697 edition differs from this 1698 one in two distinct ways: The first sections are the same, but the 1698 edition’s second section begins with “De structure glandularum,” while that piece constitutes the third section of the first edition. Both the editions have separate title-pages for this section, but the 1697 edition’s says “Lond., R. Chiswell, 1697” and includes an engraved frontispiece, while the 1698 edition’s reads “Epistola, Regiæ Societati, Londini ad Scientiam Naturalem promovendam inftitutæ, Dicata” and has no such frontispiece. Essentially, “De structure glandularum” has been moved from the end of the book in the first edition to the beginning of section 2 in the second. The first edition’s second section does is not separated by a title-page, but this piece appears at the end with its own title-page and engraved frontispiece. The first edition’s second section does have its own title-page, but has no engraved frontispiece for the section. Both editions have a separate title-page to mark Giraldus? piece. “Before his death Malpighi arranged for many of his manuscripts…to be translated into Latin by his friends Silvestro Bonfiglioli and Giovanni Lodovico Donelli and published posthumously by the Royal Society” (Meli, p. 112). His Omnia Posthuma contains “replies to his antagonists Michele Lipari, dating from his stay at Messina, and Professor Gerolamo Sbaraglia of Bologna” that are more combative in tone than what is characteristic his works published during his lifetime (Heilbron, p. 485). Malpighi was an Italian anatomist and microscopist, after whom many physiological features are named. He taught at both Bologna and Messina, before being summoned to Rome to serve as chief physician for Pope Innocent XII in 1691. Malpighi was ahead of his time, and rejected some archaic notions about diseases being caused by an imbalance in the “humors.” “On the innocent quality of human bile there occurs to me a good remark made by Malpighi (Opera Posthuma, p. 22). During the rage of a severe epidemical distemper in Pisa, in 1661, the philosopher Borelli wrote to Malpighi for his opinion concerning it. Malpighi, in his reply, observes, among other things, that the bile cannot be the cause of that disease, because in cases where large quantities of that fluid are mingled with the blood, as in jaundice and other similar diseases, no fever is occasioned thereby…. This single objection is fatal to the hypothesis, and conclusive against the origin of fevers from absorbed bile” (Mitchell & Miller, p. 117). PROVENANCE: Christoph von Hellwig (1663-1721), a German physician whose works covered a variety of topics including botany, chemistry, pharmacology and veterinary medicine. He was brother to Johann Otto von Hellwig (1654-1698), a professor of medicine (at Heidelberg) and physician practicing in Batavia. Christoph accompanied his brother on numerous trips to the Netherlands, Portugal, Italy, and England during his lifetime. (Poggendorff, Vol. 1, p. 1058). “The German physician Hellwig … was an elusive personage who moved his practice repeatedly from city to city and who wrote or edited (but never dated) more than 40 medical and pharmaceutical books, many of which were dictionaries, household medical guides, and reports of unusual cases” (Heirs of Hippocrates 717.1 [referring to Hellwig’s Nosce te ipsum (1716)]). Gustav Wilhelm Henrici [also: Gustavus Guilielmus Henrici] was another German physician, and proves even more elusive than Hellwig. Henrici published at least one book during his lifetime, on female fertility: Observationes de ovis muliebribus foecundis et sterilibus (Erlangen: Camerarius, 1763). John S. Ely, M.D. (d. 1906), took his B.A. in 1881 at the Sheffield Scientific School and became Professor of the Theory and Practice of Medicine at Yale in 1898 (“Medical School Catalogue”). In 1896/97 he left the College of Physicians and Surgeons, New York, where Ely held the position of “Assistant of Pathology and Curator”, Bellevue Hospital. Ely wrote a pamphlet, “A Study of Metastatic Carcinoma of the Stomach; report of a case of primary carcinoma of the testicle; secondary involvement of the Vena Cava Interior; Metastases in the Lungs, Stomach and Faix Cerebri,” American Journal of The Medical Sciences, 1890. He wrote a paper “Diabetic Coma,” [Yale Medical Journal, (1900), vol. 7, pp. 111-124]; another paper, “Mummification: one of the results of retention of a dead foetus in utero,” Medical Record, Jan. 25, 1890, pp. 90-1. According to the Bulletin of Yale University, 3rd. Ser., no. 10, Aug. 1907, Ely was also an expert binder. Heilbron, John, “Malpighi, Marcello,” Oxford Companion to the History of Modern Science, Oxford: Oxford University Press, 2003; Heirs of Hippocrates 717.1; “Medical School Catalogue,” Yale Daily News, Vol. XXI, No. 79, 1898; Meli, Domenico Bertolini, “The Archive and Consulti of Marcello Malpighi: Some Preliminary Reflections,” Ed. Michael Cyril William Hunter, Archives of the Scientific Revolution: The Formation and Exchange of Ideas in Seventeenth-century Europe, Rochester, NY: Boydell & Brewer, 1998, 109-120 pp.; Mitchell, Samuel Latham & Edward Miller, The Medical Repository of and Review of American Publications on Medicine, Surgery, and the Auxiliary Branches of Philosophy, Vol. 5, New York: T. & J. Swords, 1802; Petrus, Jacob, “L. Christoph: Hellwig Jacob Petrus Sc. Erssurti,” NLM, available on-line; Poggendorff, Vol. 1, p. 1058; Yale University, Directory of the Living Graduates of Yale University, 1904, New Haven, CT: Tuttle, Morehouse & Taylor, 1904. Full title: Opera Posthuma. In quibus Excellentissimi Authoris vita continetur, ac pleraque quæ ab ipso priùs scripta aut inventa sunt confirmantur, & ab adversariorum objectionibus vindicantur. Supplementa necessaria, & Præfationem addidit, innumerisque in locis emendavit Petrus Regis Monspeliensis, in Academiâ patria Medicine Doctor. Editio ultima figuris æneis illustrata, priori longe præferenda. First Edition. 
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6 PARE, Ambroise (1510-1590). Opera Ambrosii Parei Regis Primarii et Parisiensis Chirvrgi. A Docto viro plerisque locis recognita: Et Latinitate donata, Iacobi Gvillemeav, Regij & Parisiensis Chirurgi labore & diligentia. Ad Clarissimum virum Marcvm Mironem Regis Archiatrum dignissimum.
Parisiis, Apud Iacobvm Dv-pvys, 1582. 1582 
Folio in sixes (351 x 208 mm) [12], 884, [22] pp. Collated complete: ã6, A-Z6, Aa-Zz6, AA-ZZ6, AAa-DDd6, EEe4, FFf-GGg6, index, errata leaf, woodcut of Pare, aged sixty-eight, on verso of ã4, 362 woodcuts; lightly foxed, title-page and 2 ff. following re-margined, a few repairs, not affecting text or images, some damp-staining, occasional early in k underlining and marginal notes showing early evidence of reading the text. Contemporary limp full vellum, m.s. spine title. Very good. FIRST LATIN EDITION; third edition overall. ?No third French edition appears to have been published, its place supposedly being taken by the first Latin translation in 1582… This, the first Latin edition, has been long regarded as taking the place of a third French edition, since no third has ever been found and since this one lies between the second, 1579, and the fourth, 1585, edition of the Oeuvres… I think we can take it as conclusive that the 1582 Opera represented to Pare his third edition. It must at least have been planned as early as 1577, when he failed to include, among those he gave to Viart as a wedding gift, the books which were still to be published ‘as well in Latin as in French’? [Doe]. ?The reputed translator-editor, Jacques Guillemeau, was an excellent classical scholar and the lifelong friend of Pare… But although Pare’s Opera is known as Guillemeau’s translation, and is so indicated on the title-page, it was in reality the work of someone else, unidentified, Guillemeau states, in his dedication to Miron, that the translation was, in fact, made by a friend who did not wish his name to appear.? [Doe] In the process of being translated from the French into Latin, the work became available to all the nations of Europe as Latin was the lingua franca of scholarship. But, unfortunately, the translator, ?took great liberties with the French text: using the second edition of 1579, he altered, inserted, subtracted even whole chapters, where it suited him. He sometimes inverts the original order and sometimes paraphrases the text…The translation cannot be trusted, except with reservations, but it is at least useful to consult where the original is difficult to understand. The shortcomings of this edition are the more distressing in that they are, of course, continued in al the subsequent editions based on this one, namely, the Latin, English, and German editions.? [Doe]. ?The fifth and most complete edition, containing the first printing of Pare’s final revisions, was published in Paris, 1598. English translation by Thomas Johnson, London, 1634 (from the 1582 Latin translation of the second [1579] edition.? [Garrison & Morton]. References: BM Readex Vol. 19, p. 354; Cushing P88, Doe, A bibliography of the Works of Ambroise Pare, #46, pp. 90-91, 153-160; Durling/NLM 3531; Garrison & Morton 5565; Heirs of Hippocrates 271; Osler 661; Waller 7175; Wellcome 4824. First Edition. 
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7 SYLVIUS, Francois de le Boe, (1614-1672). Francisci Deleboe, Sylvii … Opera Medica, hoc est, Disputationum medicarum decas, Methodi methendi libri duo …
Genevae, Apud Samuelem de Tournes, 1681. 1681 
358 x 232 mm. Large 4to. [18], 747, [39] pp. Title printed in red & black; title vignette, woodcut initial letters. Lacking frontis. portrait and half-title [both supplied in photocopy facs.], a few prick marks on title margins, usual occasional browning and spotting throughout. Modern quarter tan calf, marbled boards, white tips, maroon morocco spine label, new endleaves. Early ownership inscription: "Petri Martini Borrini, ... Michaelis Antonii Moni Gallieanensis." Nine line ink ms. inscription at final blank. Foot of title with initials "P.M.B." [=Petri Martini Borrini?]. Near fine. FIRST GENEVA EDITION, posthumously published edition of Sylvius’ collected works, issued one year after the Amsterdam Opera Medica. He is known to be influenced by Paracelsus and an early supporter of William Harvey’s theory on the circulation of the blood. "Tuberculosis was known to the ancients only in its advanced form, and little progress was made in the knowledge of the condition until the time of Sylvius. He asserted that tubercles are often to be found in the lung and that they softened and suppurated to form cavities." Le Boe made his observations in 1650, but his De phthisi was published in his Opera in 1679. This edition of his collected works contains his writings in medical and chemical fields. Le Boe was an early and ardent supporter of Harvey’s theory of the circulation of the blood. Contents: Disputationum Medicarum – De Methodo Medendi Liber I - ... Liber II - Praxeos medicae idea nova ... I – Liber II – De Morbis Infantum [on epidemics, pests, diseases] – Opuscula Varia – De Infimo Ventre Libr. I – De Media Cavitate Lib. II – De Suprema Cavitate Lib. III. Francois de le Boe (1614-1672), Dutch physician, often known by his Latinized name, Franciscus Sylvius, was born in Hanau, Germany, studied medicine at the Protestant Academy of Sedan. He was a "very popular and respected" teacher at the University of Leiden. Among his most prominent students were DeGraaf (of graafian follicle fame); Stensen (of Stensen's duct fame); Swammerdam, who discovered red blood cells; and Van Horne, who discovered the thoracic duct in man. His most famous student was Thomas Bartholinus, who, during the process of updating the medical text written by his father, Caspar, first published [Francois] Sylvius’ neuroanatomical work and very accurate description of the lateral cerebral sulcus" [op.cit.]. His description of neuroanatomy and especially the dural venous sinuses, are important contributions in the history of medicine. In creating the first academic chemical laboratory he "fathered the theoretical framework called iatrochemistry that modernized the Galenic humoral theory by integrating it with chemical information being discovered at the time." [op.cit.]. Castiglioni, pp. 540-1; DSB, XIII, p. 223; Garrison and Morton 2321; Osler 4063; Partington II, pp. 281-90. 
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